1 Ruby and 2 Gul Rune will give you Vex Rune. 1 Sapphire and 2 Ist Rune will give you Gul Rune. 1 Amethyst and 2 Mal Rune will give you Ist Rune. 
1 Topaz and 2 Um Rune will give you Mal Rune. 1 Flawed Diamond and 3 Pul Rune will give you Um Rune. 1 Flawed Emerald and 3 Lem Rune will give you Pul Rune. 1 Flawed Ruby and 3 Fal Rune will give you Lem Rune. 1 Flawed Sapphire and 3 Ko Rune will give you Fal Rune. 1 Flamed Amethyst and 3 Lum Rune will give you Ko Rune. 1 Flawed Topaz and 3 Io Rune will give you Lum Rune. 1 Chipped Diamond and 3 Hel Rune will give you and Io Rune. 1 Chipped Emerald and 3 Dol Rune will give you the Hel Rune. 1 Chipped Ruby and 3 Shael Rune will give you Dol Rune. 1 Chipped Sapphire and 3 Sol Rune will give you Shael Rune. 1 Chipped Amethyst and 3 Amn Rune will give you Sol Rune. 1 Chipped Topaz and 3 Thul Rune will give you Amn Rune. Thus we've added even more lesser-known Horadric Cube recipes so players can transmute to their heart's content. Missing out on some Horadric Cube recipes in Diablo 2: Resurrected can often result in handicapped gameplay since they make things simpler. It just so happens that the recipe list for the Horadric Cube is quite vast, meaning there ought to be some players out there who still haven't come across some of the more useful ones. Updated on December 31, 2021, by Sid Natividad: Everyone's Horadric Cubes are hard at work in providing players some fuel or some motivation to keep them adventuring to Hell and back. Meanwhile, some players may have been fans of the second game for two decades, but are still unaware that these recipes exist. Some of these lesser-known recipes are even crucial for the late game in Diablo 2. Runewords take the forefront of the Horadric Cube recipe lists, leaving some rarer recipes unknown by a good percentage of players. RELATED: Diablo 2: Best Mods For The Game (& How To Install Them) The Horadric Cube is the biggest offender here, and Runewords are the best example of how much players needed monumental experimentation in order to come up with a list that many players take for granted. 
It doesn't help that many of these mechanics are poorly explained, and require some expensive trial and error. Being a 20-year-old game, Diablo 2is making lots of players' heads itch with its complex and archaic game mechanics.
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